Snail Protein Family in Drosophila Neurogenesis: a Dissertation
نویسندگان
چکیده
................................................................................ ...... CHAPTER I: INTRODUCTION.......................................................... ... OVERVIEW................................................................................... . Brief account of Drosophila embryonic development.................................. Maternal Genes in Development. . .
منابع مشابه
The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila.
Delaminated neuroblasts in Drosophila function as stem cells during embryonic central nervous system development. They go through repeated asymmetric divisions to generate multiple ganglion mother cells, which divide only once more to produce postmitotic neurons. Snail, a zinc-finger transcriptional repressor, is a pan-neural protein, based on its extensive expression in neuroblasts. Previous r...
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In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...
متن کاملDelaminated neuroblasts in Drosophila function as stem cells during embryonic central nervous system
The Snail protein family contains a key signature of four to six conserved zinc fingers. These proteins function as transcriptional regulators during embryonic development, cancer formation and apoptosis (Hemavathy et al., 2000; Manzanares et al., 2001). Drosophila Snail was the first member identified and shown to be a repressor essential for mesoderm development (Grau et al., 1984; Nusslein-V...
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The Drosophila Snail protein is a transcriptional repressor that is necessary for mesoderm formation. Here, we identify the Ebi protein as an essential Snail co-repressor. In ebi mutant embryos, Snail target genes are derepressed in the presumptive mesoderm. Ebi and Snail interact both genetically and physically. We identify a Snail domain that is sufficient for Ebi binding, and which functions...
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The Drosophila snail (sna) gene is first expressed in cells giving rise to mesoderm and is required for mesoderm formation. sna is subsequently expressed in the developing nervous system. sna expression during neurogenesis evolves from segmentally repeated neuroectodermal domains to a pan-neural pattern. We have identified a 2.8 kb regulatory region of the sna promoter that drives LacZ expressi...
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